PhD student (m/f/d) cardiovascular and infectious diseases

https://www.nature.com/naturecareers/job/12796235/phd-student-m-f-d-/?LinkSource=PremiumListing

PhD student (m/f/d)

Medizinische Klinik I (Kardiologie)

Scope of duties

Our group focuses on both basic experimental and translational approaches to investigate the crosstalk between innate immune cells, platelets and plasmatic factors in the context of cardiovascular and infectious diseases.

You will use a broad range of in-vitro and in-vivo methods to dissect the interplay between neutrophils and platelets in the setting of both sterile and pathogen-driven inflammation
State-of-the-art methods include transgenic mouse models with cell type-specific knockout mice, a broad range of clinically relevant models of cardiovascular disease and inflammation, superresolution in-vivo microscopy as well as as multi-omics approaches including single-cell RNA sequencing, bulk RNA sequencing, multi-panel flow cytometry and proteomics
You will be able to correlate and validate your experimental findings with clinical samples, comprising a broad biobank with hundreds of patients with cardiovascular diseases
You will contribute to the acquisition of multi-omics data from cryoconserved patient-derived samples, working in close collaboration with clinicians to assess patient outcomes
You will present the results at project meetings and publish them in high-ranking scientific journals

The Department of Cardiology is funded by and embedded into various collaborative research centers and graduate schools of the German Research Foundation (DFG), including the DFG CRC1123, CRC914. Further funding is provided by the Else Kröner-Fresenius-Stiftung and the European Research Council.

Our requirements

We require the applicant to have a major interest in cardiovascular immunology and innate immunity
Previous experience with handling of mice, especially surgical techniques, is favoured
Experience with the analysis of experimental data and high-throughput data ((sc)RNA-seq, proteomics, etc.) is a plus
We expect strong communication and teamwork skills

Our offer

We provide an interdisciplinary team of medical doctors, biologists and bioinformaticians, jointly working on cardiovascular immunology and innate immunity, using both classical immunological approaches and broad multiomic measures. We further provide a diverse range of mechanistic in-vitro models and state-of-the-art murine disease models for reverse translation of the key targets identified by multiomics. A PhD or a Dr. rer. nat., Dr. biol. hum., Dr. med. are possible. In addition, we offer further education and training, childcare services, mobile work (if suitable), company pension scheme, job ticket, discounts, and staff accommodation.

Disabled persons will be preferentially considered in case of equal qualification. Presentation costs cannot be refunded. For further information please contact Dr. Rainer Kaiser, phone: +49 89 4400-44188.

Apply now

LMU Klinikum – Campus Großhadern
Medizinische Klinik I (Kardiologie)
Marchioninistraße 15, 81377 Munich, Germany